Steroid-sparing drugs in children and young adults with nephrotic syndrome: a target trial emulation
Using real-world data, there was no difference in relapse rates after rituximab vs. calcineurin inhibitors among children and young adults with steroid-sensitive nephrotic syndrome. Steroid-sparing immunosuppression selection should be a shared decision, considering medication-specific side-effects, costs, access, duration, and adherence.
Authors
- Michelle Hladunewich
- Jovanka Vasilevska‐Ristovska (ORCID: https://orcid.org/0000-0002-1465-2523)
- Pietro A. Canetta (ORCID: https://orcid.org/0000-0003-1130-5486)
- Cal Robinson (ORCID: https://orcid.org/0000-0002-2223-0646)
- Jason M. Kidd (ORCID: https://orcid.org/0000-0002-9395-9813)
- Chia Wei Teoh (ORCID: https://orcid.org/0000-0002-5994-0799)
- Larry A. Greenbaum (ORCID: https://orcid.org/0000-0002-2490-021X)
- Josefina Brooke
- Ashlene Maree McKay (ORCID: https://orcid.org/0000-0002-8880-1886)
- Rachel Pearl
- Anna Heath (ORCID: https://orcid.org/0000-0002-7263-4251)
- Mackenzie Garner
- Maria Larkina (ORCID: https://orcid.org/0009-0002-9267-0433)
- Rulan S. Parekh (ORCID: https://orcid.org/0000-0001-6313-5752)
- Nowrin Aman
- Gabriel Cara‐Fuentes (ORCID: https://orcid.org/0000-0002-4164-3251)
- Margaret Helmuth (ORCID: https://orcid.org/0000-0003-3311-3223)
- Christoph P. B. Licht (ORCID: https://orcid.org/0000-0003-4168-3277)
- Nithiakishna Selvathesan (ORCID: https://orcid.org/0000-0001-7780-9260)
- Kimberly Reidy
- Tonny Banh (ORCID: https://orcid.org/0000-0002-5857-7641)
- Vaneet Dhillon
- Seetha Radhakrishnan (ORCID: https://orcid.org/0000-0003-1102-7623)
Institutions
- Royal Statistical Society (GB)
- Nationwide Children's Hospital (US)
- Sunnybrook Health Science Centre (CA)
- Emory University (US)
- Virginia Commonwealth University (US)
- University of Toronto (CA)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Hospital for Sick Children (CA)
- Women's College Hospital (CA)
- Health Sciences Centre (CA)
- Michigan Medicine (US)
- Public Health Ontario (CA)
- William Osler Health System (CA)
- Children's Hospital at Montefiore (US)
- SickKids Foundation (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Institute for Work & Health (CA)
- Statistical Service (CY)
- Statistical Research (United States) (US)
- University College London (GB)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1093/ndt/gfaf207
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43