A Study of Renal Insufficiency and the Risk of Developing Three Types of Fractures, with Results from Cross-Sectional Analysis and Mendelian Randomization

This study aims to explore the correlation between renal insufficiency and three common types of fractures. An observational study was conducted using NHANES data from 1999 to 2010 (20,292 participants, weighted to 145,742,649 people). After weighted multivariate adjusted logistic regression analysis, it was found that renal insufficiency is a risk factor for the three types of fractures, and the negative correlation remains significant after adjusting for covariates. Mendelian randomization analysis showed that renal insufficiency has a causal relationship only with wrist fractures (IVW: OR = 1.0003, CI = 1.00004 - 1.00050, p = 0.02). The conclusion indicates a significant correlation and partial causal relationship between the two, and it is necessary to pay attention to the fracture risk of patients with renal insufficiency, explore the related mechanisms, and conduct in-depth research.