Teneligliptin and empagliflozin attenuate ferroptosis-mediated acute tubular injury
TG and EMPA attenuate tubular cell death and kidney injury in ferroptosis-mediated AKI models, potentially through the reduction of lipid peroxidation. These findings highlight ferroptosis suppression as a potential mechanism underlying their renoprotective effects in AKI prevention.
Authors
- Tomoyuki Fujikura (ORCID: https://orcid.org/0000-0001-8143-8845)
- Naro Ohashi (ORCID: https://orcid.org/0000-0001-7023-1638)
- Ken Sugimoto (ORCID: https://orcid.org/0000-0001-9586-1097)
- Shinsuke Isobe (ORCID: https://orcid.org/0000-0002-5730-4836)
- Naoko Katahashi
- Takamasa Iwakura (ORCID: https://orcid.org/0000-0003-2647-7504)
- Akihiko Kato (ORCID: https://orcid.org/0000-0001-8238-5781)
- Sayaka Ishigaki
- Atsushi Kitamura
- Chiemi Ema (ORCID: https://orcid.org/0000-0001-8629-0093)
- Hideo Yasuda (ORCID: https://orcid.org/0000-0002-2574-8002)
- M. Tsuchida
- Takayuki Tsuji (ORCID: https://orcid.org/0000-0003-3120-5562)
- Yasushi Nakayama
Institutions
- Hamamatsu University (JP)
- Hamamatsu University School of Medicine (JP)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1093/ndt/gfaf203
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04