Neonatal enteral antibiotics reduce gut inflammation and delay systemic immune development in preterm pigs
Neonatal antibiotics attenuate gut inflammation and systemic immune development. Effects persist after cessation of antibiotic treatment. Inflammatory pathways in blood are associated with gut health parameters. This study underscores the complex interplay between gastrointestinal health and systemic immune function. Neonatal antibiotics may influence risk of infectious complications even after treatment.
Authors
- Per Torp Sangild (ORCID: https://orcid.org/0000-0002-5462-7760)
- Ziyuan Wu (ORCID: https://orcid.org/0000-0001-9743-4072)
- Duc Ninh Nguyen (ORCID: https://orcid.org/0000-0002-4997-555X)
- Anders Brunse (ORCID: https://orcid.org/0000-0002-0199-3417)
- René Liang Shen (ORCID: https://orcid.org/0000-0002-4818-4377)
- Shuqiang Ren (ORCID: https://orcid.org/0009-0006-1300-2592)
- Xiaoyu Pan (ORCID: https://orcid.org/0000-0002-0282-6047)
Institutions
- University of Copenhagen (DK)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1038/s41390-025-04436-9
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88