Characterization of a sesquiterpene synthase and a short-chain dehydrogenase in zerumbone biosynthesis and the applications in engineered Saccharomyces cerevisiae
This study expands the genetic toolkit for zerumbone biosynthesis and provides insights into enzyme engineering and metabolic engineering strategies to enhance production. Limitations in precursor supply and catalytic efficiency highlight areas for future optimization.
Authors
- Jing Ma (ORCID: https://orcid.org/0000-0003-1177-1305)
- Qiuhui Wei
- Mengdie Xu (ORCID: https://orcid.org/0009-0005-5646-3500)
- Dengyu Li
- Gao‐Li Fang (ORCID: https://orcid.org/0009-0009-1697-6693)
- Tangli Li
- Ye Xia (ORCID: https://orcid.org/0000-0002-1548-0567)
- Lichan Tu (ORCID: https://orcid.org/0000-0003-1961-5956)
- Tianyuan Hu (ORCID: https://orcid.org/0000-0002-8145-5802)
- Xiaopu Yin
Institutions
- Hangzhou Normal University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- China Academy of Chinese Medical Sciences (CN)
- Zhejiang Medicine (China) (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Plant Science
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fpls.2025.1635141
- Primary Topic
- Plant biochemistry and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Hangzhou Normal University
- Natural Science Foundation of Zhejiang Province