Computational Fluid Dynamics Modeling of Intravitreal Ranibizumab Bolus Versus Subretinal ABBV-RGX-314 Transgene Product in Human Eyes
CFD modeling effectively bridges limited human ocular PK data with rich preclinical data, supporting model-informed drug development (MIDD) for clinical dose selection.
Authors
- Mitalee Tamhane (ORCID: https://orcid.org/0000-0002-4900-6708)
- Jenny Park (ORCID: https://orcid.org/0000-0002-8177-5777)
- Jie Shen (ORCID: https://orcid.org/0000-0002-2779-079X)
- Mohammad Reza Kazemi (ORCID: https://orcid.org/0000-0002-8932-0769)
Institutions
- AbbVie (United States) (US)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1167/tvst.14.10.6
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00