The Transcription Factor Islet-1 Regulates Diabetes-Induced Inner Blood-Retinal Barrier Disruption
Our results establish Islet-1 as a critical regulator of iBRB disruption in diabetic retinopathy and suggest that targeting Islet-1 overexpression may represent a novel therapeutic approach to mitigate iBRB dysfunction and its associated retinal pathologies.
Authors
- Tingting Feng (ORCID: https://orcid.org/0000-0003-1285-8779)
- Guoli Zheng (ORCID: https://orcid.org/0000-0001-5471-1797)
- Xueyong Zhang (ORCID: https://orcid.org/0000-0001-5639-7949)
- Xiaobo Xia (ORCID: https://orcid.org/0000-0002-2785-3391)
- Siqi Xiong (ORCID: https://orcid.org/0000-0002-1281-8198)
- Die Liu (ORCID: https://orcid.org/0000-0002-3918-0569)
- Wanpeng Wang (ORCID: https://orcid.org/0000-0002-4201-895X)
- Quyan Zhang
- Zhenyu Li (ORCID: https://orcid.org/0000-0002-9285-0277)
- Nan Wang (ORCID: https://orcid.org/0000-0002-0983-3389)
- Wenji Xu
- Yao Xu (ORCID: https://orcid.org/0000-0003-4601-665X)
- Fei Yao (ORCID: https://orcid.org/0000-0002-1769-9140)
- Wenbo Lei
- Yiming Zhu (ORCID: https://orcid.org/0000-0002-1267-2897)
Institutions
- Central South University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1167/iovs.66.13.8
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- National Key Research and Development Program of China