Innate immune cell subsets are enriched in synovial fluid of ACPA-negative rheumatoid arthritis and characterized by distinct type I IFN gene signatures
This study identifies a distinct innate cell composition and type I IFN gene response in synovial joints, but not in peripheral blood, of patients with ACPA- RA. Similar IFN levels across groups suggest the IFN signature may have been primed before the cells entered the joints. These findings provide a foundation for future research on type I IFN responses in ACPA- RA.
Authors
- Marc H. Wadsworth (ORCID: https://orcid.org/0000-0001-9479-8516)
- Chirag Krishna (ORCID: https://orcid.org/0000-0002-9166-4632)
- Aaron Winkler (ORCID: https://orcid.org/0000-0001-7365-795X)
- Alexandra Argyriou (ORCID: https://orcid.org/0000-0002-4181-927X)
- Marie Wahren‐Herlenius (ORCID: https://orcid.org/0000-0002-0915-7245)
- Lars Rönnblom (ORCID: https://orcid.org/0000-0001-9403-6503)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Sara Turcinov (ORCID: https://orcid.org/0000-0002-7476-1019)
- Salim Ghannoum (ORCID: https://orcid.org/0000-0003-1455-5835)
- Aase Hensvold (ORCID: https://orcid.org/0000-0002-7669-3777)
- Maija‐Leena Eloranta (ORCID: https://orcid.org/0000-0002-8454-1351)
- Vivianne Malmström (ORCID: https://orcid.org/0000-0001-9251-8082)
- Karine Chemin (ORCID: https://orcid.org/0000-0002-2597-7809)
- Merel Sijbranda
- Christina Gerstner (ORCID: https://orcid.org/0009-0003-4342-4241)
- Ana Cristina Gonzalez-Sanchez
- Joshua Fienman
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Pfizer (United States) (US)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1016/j.ard.2025.07.029
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet
- Vetenskapsrådet
- Reumatikerförbundet