Lego Self-Assembly Model of Zebrafish RGB Cone Pentamer Formation: Unique Role of Crumbs2b in Cone Coalescence via Planar Orientational Cell Adhesions

We propose a Lego self-assembly model as a theory to explain the formation and maintenance of RGB cone pentamers. This model has six elements, among which Crb2b may regulate the geographical distribution and strengths of planar orientational cell adhesions (pOCA). This model exemplifies how distinct OCAs can promote self-assembly of various tissue architectures.