In vitro antimicrobial activity and resistance mechanisms of cefiderocol against clinical carbapenem-resistant gram-negative bacteria
Cefiderocol is highly effective against CRGNB; however, resistance may arise through diverse mechanisms, including efflux pump activity. Continued surveillance of emerging resistance is essential to guide its optimal clinical use.
Authors
- Yunyun Zou (ORCID: https://orcid.org/0000-0002-1565-2330)
- Liya Wang (ORCID: https://orcid.org/0000-0003-3496-6084)
- Xiaoli Cao (ORCID: https://orcid.org/0000-0001-5928-6304)
- Shen Han (ORCID: https://orcid.org/0000-0002-0900-6922)
- Ruyu Yan (ORCID: https://orcid.org/0000-0002-7589-6505)
- Jinhua Yuan
- Jun Ji
Institutions
- Jiangsu University (CN)
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Municipal Center for Disease Control And Prevention (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fmicb.2025.1670179
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Natural Science Foundation of China
- Nanjing University