Cytotoxic cycloartane-type triterpenoids from the leaves of <i>aglaia shawiana</i>

Three cycloartane-type triterpenoids have been isolated from the leaves of <i>Aglaia shawiana,</i> and the structure was determined as a new compound Shawianin A (<b>1</b>), along with two known compounds cycloartane-3<i>β</i>,29-diol-24-one (<b>2</b>), and (24 <i>R</i>)-cycloartane-3<i>β</i>,24,25- triol (<b>3</b>). Their structures were elucidated on the basis of 1D and 2D-nuclear magnetic resonance (NMR) analysis, as well as high-resolution mass spectrometry (HR-MS), infrared (IR), and ultraviolet (UV). Comparative data analysis was also carried out with appropriate reference journals and through a biosynthesis approach of the cycloartane type of triterpene compound. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed cytotoxicity with IC₅₀ values of >100 µg/ml.