Metabolomic landscape of fetal organ development during late gestation in mice

Metabolism is the critical basis for mammalian physiological functions. The systematic metabolic characteristics of major organ development during late gestation to adapt to postnatal environmental changes are still absent. Here, we detected metabolic patterns of the ICR mouse fetal organs, including the heart, stomach, liver, brain, and placenta, from embryonic days (E)15.5 to 19.5 using liquid chromatography-mass spectrometry combined with RNA sequencing and proteomics data. Our metabolic and multi-omics data showed that organs exhibited their unique metabolic characteristics during late gestation, and significant metabolic pattern transitions, especially the enhancement of digesting the fatty acids and proteins, occurred at the E16.5 to E18.5 stage. Additionally, we found the abundance of carnosine and histidine in the placenta may serve as a way to test their levels in the newborn brain in vitro. Our dataset provides a comprehensive metabolic landscape of mammalian organ development in late gestation.

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Publication Details

Journal
Communications Biology
Published
2025-10-03
DOI
https://doi.org/10.1038/s42003-025-08820-3
Citations
3
Primary Topic
Birth, Development, and Health
Type
article
Field-Weighted Citation Impact
10.48

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article

Metabolomic landscape of fetal organ development during late gestation in mice

Jing Xu, Xiaodong Li, Chanyi Li, Biao Xu et al.
3 citations
Communications Biology
Birth, Development, and Health
10.48
article

Metabolomic landscape of fetal organ development during late gestation in mice

Jing Xu, Xiaodong Li, Chanyi Li, Biao Xu, Jinfeng Xue, Hongli Yan, Jiaying Qin, Zhigang Xue, Wuping Liu, Yi Ning, Bo Lv
article en
3 citations

Abstract

Metabolism is the critical basis for mammalian physiological functions. The systematic metabolic characteristics of major organ development during late gestation to adapt to postnatal environmental changes are still absent. Here, we detected metabolic patterns of the ICR mouse fetal organs, including the heart, stomach, liver, brain, and placenta, from embryonic days (E)15.5 to 19.5 using liquid chromatography-mass spectrometry combined with RNA sequencing and proteomics data. Our metabolic and multi-omics data showed that organs exhibited their unique metabolic characteristics during late gestation, and significant metabolic pattern transitions, especially the enhancement of digesting the fatty acids and proteins, occurred at the E16.5 to E18.5 stage. Additionally, we found the abundance of carnosine and histidine in the placenta may serve as a way to test their levels in the newborn brain in vitro. Our dataset provides a comprehensive metabolic landscape of mammalian organ development in late gestation.

Communications BiologyVol. 8(1)
Hebei Medical University (CN), Tongji University (CN), Central South University (CN), Second Military Medical University (CN), First Affiliated Hospital of Hebei Medical University (CN), Xiangya Hospital Central South University (CN), Tongji Hospital (CN)
Natural Science Foundation of Shanghai, National Natural Science Foundation of China
Openalex Percentile: Top 2%
Birth, Development, and Health
10.48
DOIOpen Access PDFOpenAlex
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