Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation

Our study identified four hub IRDEGs that may serve as potential diagnostic indicators and therapeutic targets for PE. These findings suggest an important role of immune dysregulation in PE pathogenesis and offer new perspectives for treatment strategies. By integrating computational predictions with experimental evidence, our work contributes to the foundation for future clinical applications, though further research including early-stage PE is needed to validate these observations.

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Publication Details

Journal
BMC Pregnancy and Childbirth
Published
2025-10-03
DOI
https://doi.org/10.1186/s12884-025-08169-9
Citations
1
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
2.06
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article

Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation

Jianbo Wu, Lidan He, Xuemei Li, Huijuan Yang et al.
1 citations
BMC Pregnancy and Childbirth
Pregnancy and preeclampsia studies
2.06
article

Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation

Jianbo Wu, Lidan He, Xuemei Li, Huijuan Yang, Xiuyan Wu
article en
1 citations

Abstract

Our study identified four hub IRDEGs that may serve as potential diagnostic indicators and therapeutic targets for PE. These findings suggest an important role of immune dysregulation in PE pathogenesis and offer new perspectives for treatment strategies. By integrating computational predictions with experimental evidence, our work contributes to the foundation for future clinical applications, though further research including early-stage PE is needed to validate these observations.

BMC Pregnancy and ChildbirthVol. 25(1)
Fujian Medical University (CN), First Affiliated Hospital of Fujian Medical University (CN)
Openalex Percentile: Top 12%
Pregnancy and preeclampsia studies
2.06
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