Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation
Our study identified four hub IRDEGs that may serve as potential diagnostic indicators and therapeutic targets for PE. These findings suggest an important role of immune dysregulation in PE pathogenesis and offer new perspectives for treatment strategies. By integrating computational predictions with experimental evidence, our work contributes to the foundation for future clinical applications, though further research including early-stage PE is needed to validate these observations.
Authors
- Jianbo Wu (ORCID: https://orcid.org/0000-0003-3319-9717)
- Lidan He (ORCID: https://orcid.org/0000-0002-7418-6886)
- Xuemei Li (ORCID: https://orcid.org/0000-0001-5455-121X)
- Huijuan Yang (ORCID: https://orcid.org/0000-0001-5355-1170)
- Xiuyan Wu (ORCID: https://orcid.org/0009-0000-9043-8927)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12884-025-08169-9
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06