In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort
Our findings support that in-utero exposure to maternal diabetes is associated with DNAm alterations in offspring. Moreover, the timing of maternal diabetes in-utero exposure (GDM or T2D) produces overlapping but distinct DNAm patterns, suggesting that the window of exposure to maternal diabetes produces different molecular modifications and may reflect, at least in part, the difference in risk for youth-onset T2D in offspring. We also identified sites in this study that have been previously associated with T2D or obesity, which may serve as potential early-life biomarkers of exposure and/or risk, warranting further investigation in longitudinal studies.
Authors
- Christy Pylypjuk (ORCID: https://orcid.org/0000-0002-4799-4837)
- Meaghan J. Jones (ORCID: https://orcid.org/0000-0003-1593-997X)
- Ola E. Salama (ORCID: https://orcid.org/0000-0001-6959-0246)
- Brandy Wicklow (ORCID: https://orcid.org/0000-0002-6080-0494)
- Yash Rawal (ORCID: https://orcid.org/0000-0003-2114-951X)
- Elizabeth Sellers (ORCID: https://orcid.org/0000-0003-3279-2017)
- Haziqa Kassim
- Priscilla Irabor
Institutions
- Manitoba Health (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13148-025-01972-3
- Citations
- 1
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Diabetes Canada
- Children's Hospital Research Institute of Manitoba