Electroacupuncture ameliorates cognitive dysfunction in T2DM rats by modulating astrocytic polarization and aberrant energy metabolism in the hippocampus via the Wnt/β-catenin pathway
EA ameliorates cognitive deficits in T2DM rats by regulating astrocyte polarization and improving hippocampal energy metabolism through activation of the Wnt/β-catenin signaling pathway. These findings suggest a promising non-pharmacological approach to treating diabetes-related cognitive impairment and highlight the role of astrocytic immunometabolism in diabetic neurodegeneration.
Authors
- Xiaolu Li
- Rui Li (ORCID: https://orcid.org/0000-0002-2745-8762)
- Jun Lin (ORCID: https://orcid.org/0000-0002-5152-6518)
- Xiao-li Wu (ORCID: https://orcid.org/0000-0003-2306-0244)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13098-025-01941-z
- Citations
- 1
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.32