Niosome-loaded silibinin and methotrexate for synergistic breast cancer combination chemotherapy: in silico and in vitro study
The designed nano-niosome, NiO@MTXSiL, is safe, stable, and has an optimal size and surface charge. It offers high drug loading capacity for co-delivering hydrophobic and hydrophilic chemotherapeutics with different anti-cancer mechanisms, improving anti-tumor response and overcoming MDR. It shows higher cytotoxicity against MDA-MB-231 breast cancer cells compared to free drugs, making it a promising candidate to combat MTX resistance in breast cancer.
Authors
- Mehran Alizadeh Aghdam (ORCID: https://orcid.org/0000-0003-3584-9250)
- Rana Jahanban‐Esfahlan (ORCID: https://orcid.org/0000-0002-5119-252X)
- Aysan Salemi (ORCID: https://orcid.org/0000-0001-7455-0302)
- Masoumeh Kaveh Zenjanab
- Niloofar Sahragardan
Institutions
- Tabriz University of Medical Sciences (IR)
- The University of Texas at El Paso (US)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12935-025-03977-7
- Citations
- 4
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Tabriz University of Medical Sciences
- University of Tabriz