Enhancing randomized clinical trials with digital twins
Digital twins (DTs) can transform randomized clinical trials by improving ethical standards, including safety, informed consent, equity, and data privacy. They also enhance trial efficiency by enabling early detection of adverse events and streamlined design. This paper explores the role of DTs in personalized medicine, from pre-clinical research to post-marketing, while addressing technological, legal, and ethical challenges in implementation.
Authors
- Dedee Frances Murrell (ORCID: https://orcid.org/0000-0003-2971-0199)
- Alireza Haghighi
- Christopher G. Bunick (ORCID: https://orcid.org/0000-0002-4011-8308)
- Amirmohammad Pasdar (ORCID: https://orcid.org/0000-0001-5071-5803)
- Mehrnaz Mostafavi (ORCID: https://orcid.org/0000-0001-7565-9908)
- Sancy Ann Leachman (ORCID: https://orcid.org/0000-0001-9140-0648)
- Hossein Akbarialiabad (ORCID: https://orcid.org/0000-0003-2018-6378)
- Ayman Grada (ORCID: https://orcid.org/0000-0002-5321-0584)
- Michelle Babb Tarbox (ORCID: https://orcid.org/0009-0003-3336-7394)
- Ehsan Safaee (ORCID: https://orcid.org/0009-0009-6581-6346)
- Farhan Shakil
Institutions
- Broad Institute (US)
- Shahed University (IR)
- Texas Tech University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- The University of Melbourne (AU)
- Washington University in St. Louis (US)
- University of Utah (US)
- Missouri Baptist Medical Center (US)
- UNSW Sydney (AU)
- Yale University (US)
- St George Hospital (AU)
- University School (US)
- Shahid Beheshti University of Medical Sciences (IR)
- Case Western Reserve University (US)
- Texas Tech University Health Sciences Center (US)
- Webster University (US)
Publication Details
- Journal
- npj Systems Biology and Applications
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1038/s41540-025-00592-0
- Citations
- 10
- Primary Topic
- Biomedical and Engineering Education
- Type
- article
- Field-Weighted Citation Impact
- 6.74