The biology of lipoprotein(a): From genetics to molecular mechanisms

While environmental factors such as inflammation and hormonal status can transiently modulate levels, genetic variation overwhelmingly dictates lifelong Lp(a) burden. As novel agents targeting Lp(a) enter late-stage clinical trials, mechanistic insights into Lp(a) biology will be essential to risk stratification and future clinical management.

Authors

Michelle B. Atallah (ORCID: https://orcid.org/0000-0003-0721-2180)
Nadim Nasrallah
Tarek Harb (ORCID: https://orcid.org/0000-0002-2573-5260)
Gary Gerstenblith (ORCID: https://orcid.org/0000-0001-6046-6812)
Thorsten M. Leucker (ORCID: https://orcid.org/0000-0003-2569-6617)

Institutions

Johns Hopkins University (US)
Johns Hopkins Medicine (US)

Publication Details

Journal: European Journal of Clinical Investigation
Published: 2025-10-03
DOI: https://doi.org/10.1111/eci.70133
Primary Topic: Lipoproteins and Cardiovascular Health
Type: article
Field-Weighted Citation Impact: 0.00

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article

The biology of lipoprotein(a): From genetics to molecular mechanisms

Michelle B. Atallah, Nadim Nasrallah, Tarek Harb, Gary Gerstenblith et al.

Oct 3, 2025

European Journal of Clinical Investigation

Lipoproteins and Cardiovascular Health

article

The biology of lipoprotein(a): From genetics to molecular mechanisms

Michelle B. Atallah, Nadim Nasrallah, Tarek Harb, Gary Gerstenblith, Thorsten M. Leucker

October 3, 2025article en

Abstract

While environmental factors such as inflammation and hormonal status can transiently modulate levels, genetic variation overwhelmingly dictates lifelong Lp(a) burden. As novel agents targeting Lp(a) enter late-stage clinical trials, mechanistic insights into Lp(a) biology will be essential to risk stratification and future clinical management.

European Journal of Clinical InvestigationVol. 56(1)

Johns Hopkins University (US), Johns Hopkins Medicine (US)

Openalex Percentile: Top 57%

Lipoproteins and Cardiovascular Health

DOI Source OpenAlex

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The biology of lipoprotein(a): From genetics to molecular mechanisms — Michelle B. Atallah, Nadim Nasrallah, et al. · European Journal of Clinical Investigation (2025) | TGRS Research Map | TGRS