A circRNA promotes esophageal squamous cell carcinoma progression by inhibiting TRIM25-mediated degradation of IGF2BP family members
Our findings reveal an oncogenic role of circLNF in ESCC by inhibiting TRIM25-mediated proteasomal degradation of IGF2BP proteins and highlight circLNF as a potential therapeutic target for ESCC.
Authors
- Shuangyan Tan (ORCID: https://orcid.org/0009-0006-2927-7558)
- Yu Liu (ORCID: https://orcid.org/0000-0002-1193-7830)
- Hulin Ma
- Lunzhi Dai (ORCID: https://orcid.org/0000-0002-3003-8910)
- Yong Peng (ORCID: https://orcid.org/0000-0002-1181-3467)
- Jiawei Guo (ORCID: https://orcid.org/0000-0001-5180-3514)
- Zhijie Xu (ORCID: https://orcid.org/0000-0003-2047-883X)
- Yidan Lin
- Abhijit Guha (ORCID: https://orcid.org/0000-0002-9605-2993)
- Yue Ming (ORCID: https://orcid.org/0000-0002-4719-0759)
- Wenrong Liu
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12943-025-02442-3
- Citations
- 2
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Pennsylvania
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University