Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro
These findings uncover a regulatory role for the Ubl domain in allosteric modulation of PLpro activity and reveal additional layers of enzymatic plasticity. Understanding these mechanisms could guide the design of future antiviral therapeutics targeting PLpro's regulatory or allosteric sites.
Authors
- J. Ganesh
- Vishal Prashar
- Mukesh Kumar (ORCID: https://orcid.org/0000-0002-3392-7481)
- Rimanshee Arya
Institutions
- Bhabha Atomic Research Centre (IN)
- Homi Bhabha National Institute (IN)
- Bhabha Atomic Research Center Hospital (IN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13062-025-00690-3
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Bhabha Atomic Research Centre