Impact of iron deficiency on therapeutic outcomes in colorectal cancer patients: a single-center cohort study
ID is closely associated with aggressive tumor biology, suboptimal response to neoadjuvant therapy, and impaired postoperative recovery. Dysregulation of iron homeostasis and ferroptosis pathways in ID patients may contribute to CRC progression. These findings highlight ID as a potential biomarker for risk stratification and suggest that targeting iron metabolism could improve therapeutic outcomes in CRC management.
Authors
- Chao Liu (ORCID: https://orcid.org/0000-0003-3706-8634)
- Haiyang Zhou (ORCID: https://orcid.org/0000-0002-6997-5047)
- Hui Yang (ORCID: https://orcid.org/0000-0001-8111-9860)
- Qingmei Huang (ORCID: https://orcid.org/0000-0002-4404-9418)
- Hao Luo (ORCID: https://orcid.org/0000-0002-2321-9924)
- Ping Zheng
- Xuan Zhang (ORCID: https://orcid.org/0000-0003-4286-0407)
- Xin Chen (ORCID: https://orcid.org/0000-0003-1871-4477)
- Bo Song (ORCID: https://orcid.org/0000-0002-7546-9482)
- Yajun Luo
- Hai Hu (ORCID: https://orcid.org/0000-0001-5345-8371)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-6697-628X)
- Lubei Rao (ORCID: https://orcid.org/0000-0002-8243-0076)
- Wuyi Wang
Institutions
- North Sichuan Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12967-025-07018-9
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China