Bone marrow mesenchymal stem cell-derived exosomes attenuate hepatic stellate cell activation through miR-223-3p-mediated mitophagy
These results suggest that BMSC-exosomes may have antifibrotic effects. The mechanism may be related to regulating miR-223-3p in HSCs to target HMGCS1 and mitophagy.
Authors
- Weidong Weng
- Feng‐Bin Lu
- Jiajia Liang
- Han Wu (ORCID: https://orcid.org/0000-0003-2359-7420)
- Lijie Ma (ORCID: https://orcid.org/0000-0002-0479-3103)
- Jie Chen (ORCID: https://orcid.org/0009-0003-2727-0289)
Institutions
- Tongde Hospital of Zhejiang Province (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12920-025-02228-y
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00