Pathological Complete Response in Locally Advanced <i>ALK</i> Fusion Gene–Positive Lung Adenocarcinoma following Salvage Surgery: A Case Report and Literature Review
This case highlights the potential role of salvage surgery following alectinib in locally advanced <i>ALK</i> fusion gene-positive NSCLC. Furthermore, it suggests that maintenance ALK-TKI therapy after salvage surgery might be associated with a reduced risk of recurrence. Further studies are warranted to optimize perioperative ALK-targeted strategies.
Authors
- Yuta Abe (ORCID: https://orcid.org/0000-0003-3427-2613)
- Miyuki Abe (ORCID: https://orcid.org/0000-0002-6570-5226)
- Atsushi Osoegawa
- Eiji Kudo (ORCID: https://orcid.org/0000-0002-9427-6619)
- Daiki Noda (ORCID: https://orcid.org/0000-0001-6997-1241)
- Naoki Haratake
- Kazuki Ohta
- Kosuke Kamada
- Tsutomu Daa (ORCID: https://orcid.org/0000-0001-5060-9883)
- Shinkichi Takamori (ORCID: https://orcid.org/0000-0001-8175-6798)
- Kenji Sugio
- Yohei Takumi (ORCID: https://orcid.org/0000-0002-1171-9243)
- Michiyo Miyawaki (ORCID: https://orcid.org/0000-0001-8158-1473)
- Takahiro Sato (ORCID: https://orcid.org/0000-0002-7628-9686)
Institutions
- Harvard University (US)
- Oita University (JP)
- Dana-Farber Cancer Institute (US)
- Oita Prefectural Hospital (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.70352/scrj.cr.25-0238
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00