Severe Recurrent Guillain-Barré Syndrome with Antibodies against Ganglioside Complexes Related to GQ1b and GD1b

We herein report a case of recurrent Guillain-Barré syndrome presenting with tetraplegia, ophthalmoplegia, respiratory failure, and autonomic dysfunction following Campylobacter jejuni infection. A glycoarray analysis revealed IgG antibodies against ganglioside complex antigens, including GQ1b and GD1b. Despite multiple immunotherapies, the patient required prolonged ventilatory support and remained bedridden for over one year. These antibodies may be associated with disease severity and serve as biomarkers.