<i>Mycobacterium intracellulare</i> Infection in a Japanese Patient with Signal Transducer and Activator of Transcription-3 Gain-of-Function Syndrome: A Case Report
Signal transducer and activator of transcription-3 (STAT3) gain-of-function (GOF) syndrome predisposes patients to autoimmunity diseases. Yet, nontuberculous mycobacterial (NTM) infections have rarely been described. We herein report a teenage Japanese patient with genetically confirmed STAT3-GOF syndrome who developed Mycobacterium intracellulare disease. Combination antimycobacterial chemotherapy reduced the bacterial burden; however, the refractory NTM infection relapsed after initiation of adjunctive tofacitinib therapy. The present case demonstrates that host-directed therapy must be combined with prolonged antimycobacterial regimens to control drug-resistant NTM in patients with inborn errors of immunity.
Authors
- Yoji Hirai (ORCID: https://orcid.org/0000-0003-2201-6129)
- Kosei Hasegawa (ORCID: https://orcid.org/0000-0002-1751-6527)
- Hideharu Hagiya (ORCID: https://orcid.org/0000-0002-5086-1891)
- Masato Yashiro
- Kazuki Tokumasu (ORCID: https://orcid.org/0000-0001-9513-6864)
- Yuki Otsuka (ORCID: https://orcid.org/0000-0001-6015-6128)
- Yoshiaki Soejima (ORCID: https://orcid.org/0000-0002-2070-3892)
- Fumio Otsuka (ORCID: https://orcid.org/0000-0001-7014-9095)
- Kazuhiro Uda (ORCID: https://orcid.org/0000-0002-2262-6130)
- Yusuke Shiode
- Shinnosuke Fukushima (ORCID: https://orcid.org/0000-0003-4871-4996)
- Kohei Oguni (ORCID: https://orcid.org/0009-0006-9020-6118)
- Kenta Nakamoto
- K. IIO
- Marina Kawaguchi
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2169/internalmedicine.6174-25
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00