Erythromycin plus metoclopramide combination therapy compared with erythromycin or metoclopramide monotherapy for postpyloric spiral nasoenteric tube placement: a multicenter, open-label, randomized controlled superiority trial
The combination therapy of erythromycin and metoclopramide was not superior to erythromycin or metoclopramide monotherapy in facilitating postpyloric placement of spiral NETs in critically ill patients. However, the combination therapy was associated with a higher incidence of drug side effects compared with the metoclopramide monotherapy. The trial was registered with https://www.chictr.org.cn/showprojEN.html?proj=33960 (trial ID ChiCTR1900022508).
Authors
- Wei‐Sheng Chen (ORCID: https://orcid.org/0000-0001-8672-180X)
- Xiangwei Huang (ORCID: https://orcid.org/0000-0003-3803-1390)
- Daoyong Huang
- Silin Liang (ORCID: https://orcid.org/0000-0002-6543-5633)
- Chunbo Chen (ORCID: https://orcid.org/0000-0001-5662-497X)
- Xiangyin Chen
- Hao Wang (ORCID: https://orcid.org/0000-0001-8657-0562)
- Bei Hu (ORCID: https://orcid.org/0000-0002-5802-1694)
- Yuting Chen (ORCID: https://orcid.org/0000-0001-6209-1890)
- Chenxi Li (ORCID: https://orcid.org/0000-0001-9660-9256)
- Cheng Sun (ORCID: https://orcid.org/0000-0002-5533-1398)
- Linhui Hu (ORCID: https://orcid.org/0000-0002-1649-6624)
- Linling He (ORCID: https://orcid.org/0000-0001-8262-2070)
- Jiajia Huang
Institutions
- Southern University of Science and Technology (CN)
- Huizhou Central People's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Qujiang People's Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- People's Hospital of Yangzhong (CN)
- Kashi University (CN)
- Shenzhen Second People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.09.043
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00