Alterations in Liver Enzymes and Histopathological Changes in an Animal Model of Polycystic Ovary Syndrome (PCOS)

Acute induction of PCOS using testosterone propionate and estradiol benzoate resulted in modest hepatocellular changes, with only SGOT levels showing a significant group difference. These findings suggest that the hepatic response is limited under the tested conditions. Future studies should consider longer exposure durations, combined metabolic stressors, and environmental controls to better simulate PCOS-associated liver dysfunction and to develop more robust animal models for therapeutic evaluation.