High Serum Phosphate Promotes Cognitive Impairment in Uremic Rats via Mediating Vascular Calcification

Taken together, these results indicated that elevated serum phosphate might promote VC in uremic rats by activating the expressions of ALP and Runx2, thereby causing damage to the kidneys and uremia-associated complications such as CI. Therefore, this study improved the understanding to possible pathogenic mechanisms of uremia-induced CI, and will be beneficial to optimize the prevention and treatment strategy for CI in uremic patients.