THBS1 regulates the function and insulin sensitivity of HTR8/SVneo cells treated with high glucose through the RhoA/ROCK1 signaling pathway
THBS1 impairs the function and insulin sensitivity of HTR8/SVneo cells by inhibiting insulin signaling and activating the RhoA/ROCK pathway. This indicates that THBS1 may play an important role in the pathogenesis of GDM and become a potential therapeutic target.
Authors
- Jie Tang (ORCID: https://orcid.org/0000-0001-7882-4462)
- Yan-Feng Chai
- Aimin Liu (ORCID: https://orcid.org/0000-0003-0099-0879)
- Qin Zhou (ORCID: https://orcid.org/0000-0001-9943-2396)
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s13098-025-01915-1
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01