Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk
A generational effect has reduced the severity of intellectual disability in Down syndrome (DS). Individuals with DS have increased autonomy and improved intellectual milestones. The enriched environment has not delayed the age at Alzheimer's disease (AD) dementia in DS. Further studies should confirm if cognitive reserve might delay AD in DS.
Authors
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Laura del Hoyo Soriano (ORCID: https://orcid.org/0000-0003-4372-1599)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Íñigo Rodríguez‐Baz (ORCID: https://orcid.org/0000-0003-3039-9115)
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Eider M. Arenaza‐Urquijo (ORCID: https://orcid.org/0000-0001-7016-7576)
- Lídia Vaqué‐Alcázar (ORCID: https://orcid.org/0000-0002-6776-6559)
- David Bartrés‐Faz (ORCID: https://orcid.org/0000-0001-6020-4118)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Lucía Maure-Blesa (ORCID: https://orcid.org/0000-0001-5643-7971)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Alejandra O. Morcillo‐Nieto (ORCID: https://orcid.org/0000-0003-2202-3521)
- Susana Fernández (ORCID: https://orcid.org/0000-0003-4154-682X)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Alberto Lleó
- Aida Sanjuan‐Hernández
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institut Guttmann (ES)
- Barcelona Institute for Global Health (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70447
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Tatiana Pérez de Guzmán el Bueno