P091 Domiciliary non-invasive ventilation in chronic Hypercapneic respiratory failure: experiences at a tertiary Australian Centre

Abstract Background Domiciliary non-invasive ventilation (NIV) is widely used to manage chronic hypercapneic respiratory failure in patients with neuromuscular disorders (NMD), obesity hypoventilation syndrome (OHS), and chronic obstructive pulmonary disease (COPD). Observational studies suggest domiciliary NIV alleviates hypoventilation-related symptoms and improves quality of life and survival. However, randomised controlled data remains limited, largely due to ethical implications of withholding potentially beneficial treatment. Since 2015, the Sleep Unit at Sunshine Coast University Hospital (SCUH) in Queensland, Australia, has coordinated the provision of domiciliary NIV devices through the Queensland Health Sleep Disordered Breathing Program (QHSDP), the National Disability Insurance Scheme (NDIS), short and long term loan devices from SCUH, and private sources. This study aims to characterise the patient population initiated on domiciliary NIV at SCUH and evaluate their outcomes, with a particular focus on patients with COPD. Method With approval from the Human Research and Ethics Committee of Metro North Health, we will conduct a retrospective cohort study of all patients initiated on domiciliary NIV devices at SCUH between 2020 and 2024. Recorded data will include demographics, comorbidities, lung function, device settings and usage, hospital admissions, and mortality. Progress to date Data collection and analysis are currently in progress. Intended outcome and impact This study will provide a review of the cohort of patients initiated on domiciliary NIV at our health service and assess its effectiveness in reducing hospital admissions and mortality. By identifying patients most likely to benefit from domiciliary NIV, we hope to improve patient selection and device provision.