P077 Association between novel cardiovascular indices and sleep duration and disturbance.

Abstract Introduction Insufficient and excessive sleep have both been linked to increased cardiovascular and all-cause mortality. Whilst the relationship between sleep duration and traditional lipid indices are well described, the connection to novel lipid and anthropometric indices remains unclear. This study examines these associations using the National Health and Nutrition Examination Survey (NHANES). Methods Data from 9847 adults from NHANES 2005-2020, excluding those with major cardiovascular disease and cancer, were analysed. Sleep duration was categorized as insufficient (<7hours), normal (7-8hours), and excessive (>8 hours). Self-reported sleep disturbance was documented. Novel indices included non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), Triglyceride to HDL-Cholesterol (TG/HDL), Triglyceride-glucose index (TyG), Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), Conicity Index (CI), Body-roundness index (BRI), A body shape index (ABSI), and Weight-adjusted waist index (WWI). Generalized additive models (GAM) with spline smoothing and threshold analysis assessed non-linear associations, adjusting for confounders. Weighted multivariate linear regression evaluated linear associations. Results Insufficient sleep was associated with higher TyG combined with waist-to-height ratio (TyG-WHtR) (p=.003). Excessive sleep was linked to higher TyG-WHtR, CI, BRI, ABSI, and WWI (p<.001). Sleep disturbance was associated with elevated TyG-WHtR, TyG-WC, LAP, CI, BRI, ABSI, and WWI (p<.001). Threshold analysis confirmed significant changes in several indices, emphasising the impact of both insufficient and excessive sleep. Discussion Insufficient sleep duration, excessive sleep duration, and sleep disturbance, are associated with adverse lipid and anthropometric profiles indicating increased cardiometabolic risk. Optimising sleep duration and minimising sleep disturbance could mitigate these risks.