Tetrahydropalmatine has analgesic role in mouse model of bone cancer pain by inactivating the TNF-α/uPA/PAR2/TRPV1 pathway in dorsal root ganglia
THP exerted the analgesic role in BCP might be through inactivating the TNF-α/uPA/PAR2/TRPV1 pathway in DRG. It may be an effective drug for relieving BCP in patients.
Authors
- Y. M. Bao (ORCID: https://orcid.org/0009-0006-4872-5934)
- Dongtao Li
- Juanxia Ren
- Linghan Meng
- Lu Shang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12935-025-03972-y
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- China Academy of Chinese Medical Sciences