Therapeutic Aspects of Post-Polio Syndrome: A Comprehensive Scoping Review

Background: Post-Polio Syndrome (PPS) is a condition that affects polio survivors years after their initial recovery, manifesting in new symptoms such as muscle weakness, fatigue, and pain. Despite its prevalence, comprehensive reviews of therapeutic approaches for managing PPS are limited. Objective: This scoping review aims to explore and summarize the current therapeutic aspects of PPS, including pharmacological treatments, physical therapies, and other interventions, to identify gaps in knowledge and areas for future research. Methods: A systematic search was conducted across multiple databases, including PubMed, Scopus, MeSH, PEDro and Cochrane Library, focusing on studies published between 2020 and 2024. Articles were screened for relevance based on predefined inclusion criteria, and data were extracted on therapeutic interventions, outcomes, and patient experiences. Results: A total of 64 studies met the inclusion criteria. The review found that physical therapy and exercise programs were the most commonly reported interventions, with evidence supporting their role in improving function and quality of life. Pharmacological treatments, including pain management and fatigue reduction, showed variable efficacy. Emerging therapies, such as neuromuscular stimulation and psychological support, were less studied but indicated promising results. Conclusion: The therapeutic landscape for PPS is diverse, with physical therapy and exercise being the most supported interventions. However, there is a need for more high-quality research to evaluate the effectiveness of pharmacological treatments and innovative therapies. Future studies should focus on longitudinal outcomes and personalized treatment approaches to better address the complex needs of PPS patients.