A Review on Arsenic Toxicity Induced Keratosis and its Prevalence

Background: Rapidly increasing discharge of arsenic (As) is a major health concern due to its cancer-causing effects.Excessive exposure of As causes the cancer of many organs including skin, liver, kidney, lungs.Precancerous skin condition due to the exposure of As is called As-keratosis, which is marked by hyperpigmentation and plaques and lump formation.The article focal point is the skin cancer which is the most concerning one.Objective: The purpose of this review article is to synthesize an up-to-date knowledge of As induced keratosis including its prevalence, diagnosis, treatment.Methodology: This review was conducted by using major database including Google Scholar and PubMed.Review findings: Toxicity due to As is a global health related issue which affect people globally.As-keratosis is inveterate clinical or subclinical deadly harmful because of the presence of As metalloid in the body at higher level.A crosssectional analysis was held to investigate the exposure of As is due to the number of reasons which includes contaminated water and sanitary landfills, etc. Diagnosis is based on the laboratory examination and histopathological examination.It is also diagnosed by the measuring the amount of As in blood, urine and hairs sample.Pathophysiology of the keratosis describe that the trivalent arsenide and methylation of As cause hyperpigmentation. Conclusion:For the prevention of As keratosis make sure the usage of As treatment plant for the availability of As free water for drinking purposes.Options for the treatment purpose include the use of the oral and topical medications and surgical excision.For the management of As keratosis nanotechnology use to remove As from ground water.