Clinical impact of computed tomography-measured skeletal muscle status at the third cervical vertebra on definitive radiotherapy outcomes for head and neck squamous cell carcinoma
Among the CT-derived body composition parameters assessed at the C3 level, low SMA was the only significant independent predictor of OS in patients with HNSCC receiving definitive radiotherapy. These findings support the clinical relevance of SMA assessment as a straightforward and robust prognostic biomarker and underscore the need for further investigation into the prognostic potential of other body composition metrics.
Authors
- Kenya Kobayashi (ORCID: https://orcid.org/0000-0002-5823-3718)
- Masanari Minamitani (ORCID: https://orcid.org/0000-0002-8851-5695)
- Osamu Abe (ORCID: https://orcid.org/0000-0002-1180-2629)
- Yuki Saito (ORCID: https://orcid.org/0000-0002-4825-7783)
- Koji Yamamura (ORCID: https://orcid.org/0000-0002-0085-5098)
- Wataru Gonoi (ORCID: https://orcid.org/0000-0002-5018-4683)
- Shouhei Hanaoka (ORCID: https://orcid.org/0000-0002-7496-1651)
- Atsuto Katano (ORCID: https://orcid.org/0000-0003-4393-1828)
- Yuki Kasuga
- Shin Fujiwara
- Hideomi Yamashita
Institutions
- University of Tokyo Hospital (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Japanese Journal of Radiology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1007/s11604-025-01888-1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tokyo