Syringomatous Tumor of the Nipple in an Adolescent Female: A Rare Cutaneous Adnexal Neoplasm With Distinct Histopathologic Features

Syringomatous tumor of the nipple (SyT) is a rare benign tumor that arises in the nipple or areolar region. Due to its locally infiltrative growth pattern, it is often misdiagnosed as a malignant tumor. SyT primarily occurs in middle-aged women, with a reported mean age of onset of 46.1 years. Fewer than 100 cases have been documented in the literature to date, and occurrence in adolescents is exceedingly rare. This case report describes a rare instance of SyT in a 16-year-old asymptomatic female, who presented with progressive unilateral nipple enlargement over 5 years. Breast ultrasound and subsequent surgical excision were performed, and the final histopathological diagnosis confirmed SyT. This report highlights the imaging and pathological features of SyT and discusses main differential diagnoses, emphasizing the importance of accurate clinical recognition and appropriate management to avoid overtreatment. It provides valuable insights to aid in the diagnosis and clinical decision-making for this rare entity.