Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study
This study examined the relationship between DAT and overall synaptic density in nigrostriatal ROIs in PD using dual-tracer PET imaging, and there were distinct patterns that vary across disease stages. Understanding the interplay between dopaminergic and presynaptic degeneration in PD could enhance our knowledge of its pathophysiology and contribute to improve diagnosis. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Jean‐Dominique Gallezot (ORCID: https://orcid.org/0000-0003-0399-8374)
- Gustavo A. Angarita (ORCID: https://orcid.org/0000-0001-5568-9878)
- Richard E. Carson (ORCID: https://orcid.org/0000-0002-9338-7966)
- Faranak Ebrahimian Sadabad (ORCID: https://orcid.org/0000-0002-6649-7211)
- Yanghong Yang (ORCID: https://orcid.org/0000-0002-6816-1252)
- Robert A. Comley (ORCID: https://orcid.org/0000-0001-7546-5492)
- Takuya Toyonaga (ORCID: https://orcid.org/0000-0002-0369-8294)
- Sophie Holmes (ORCID: https://orcid.org/0000-0002-4929-1932)
- Waleed Ibrahim (ORCID: https://orcid.org/0000-0001-9640-4090)
- Rajiv Radhakrishnan (ORCID: https://orcid.org/0000-0002-8220-655X)
- Mark Dias
- Mika Naganawa (ORCID: https://orcid.org/0000-0002-4408-2621)
- Brian Pittman (ORCID: https://orcid.org/0000-0002-0353-5604)
- Tommaso Volpi (ORCID: https://orcid.org/0000-0002-5451-6710)
- Sjoerd J. Finnema (ORCID: https://orcid.org/0000-0002-4972-3627)
- Sule Tinaz (ORCID: https://orcid.org/0000-0003-2220-8278)
- Praveen Honhar (ORCID: https://orcid.org/0000-0001-9073-6270)
- David Matuskey (ORCID: https://orcid.org/0000-0001-7508-6572)
- Salih Çayır (ORCID: https://orcid.org/0000-0002-4071-5188)
Institutions
- AbbVie (United States) (US)
- Yale University (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1002/mds.70041
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00