The BAF53A-BACH1-GCLM axis regulates glutathione metabolism and enhances ferroptosis resistance in esophageal squamous cell carcinoma
The BAF53A-BACH1-GCLM axis constitutes a novel egulatory pathway that integrates chromatin remodeling, transcriptional regulatione, and ferroptosis resistance in ESCC. Targeting this axis may offer a promising approach to exploit metabolic vulnerabilities and enhance ferroptosis sensitivity in ESCC treatment.
Authors
- Weijuan Jiang (ORCID: https://orcid.org/0000-0002-2429-7772)
- Canjuan Chen (ORCID: https://orcid.org/0009-0000-9582-2178)
- Lihua Fan (ORCID: https://orcid.org/0009-0007-5023-3637)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-9184-0587)
- Jiangwei Shi
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Northern Jiangsu People's Hospital (CN)
- First People's Hospital of Jingzhou (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-10-03
- DOI
- https://doi.org/10.7717/peerj.20156
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00