An organoplatinum-bridged conjugated polymeric photosensitizer with a donor–acceptor structure for enhanced photodynamic efficiency and integrated tumour therapy
A conjugated polymer P1 with an organoplatinum-bridged BODIPY-fluorene structure is developed for synergistic photodynamic, photothermal and chemotherapy. P1 nanoparticles exhibit strong NIR absorption, enhanced reactive oxygen species (ROS) generation and high photothermal conversion, demonstrating superior antitumour efficacy under NIR irradiation. This work highlights the great potential of conjugated polymer-photosensitizer hybrids with built-in chemotherapeutic modules as a new paradigm for combinatorial tumour treatment.
Authors
- Shouchun Yin (ORCID: https://orcid.org/0000-0003-1086-1755)
- Yuanping Yi (ORCID: https://orcid.org/0000-0002-0052-9364)
- Gang Wen (ORCID: https://orcid.org/0000-0002-0121-1665)
- Shenglong Liao (ORCID: https://orcid.org/0000-0002-2118-2515)
- Zhen‐Yu Tian (ORCID: https://orcid.org/0000-0003-1497-3762)
- Xiangyuan Mao
Institutions
- Hangzhou Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05313g
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00