Quantitative temporal analysis of pancreatic islet T lymphocyte and macrophage infiltration heralded by serum IgE in congenic BioBreeding (BB) Gimap5−/− rats at risk for insulitis and acute onset diabetes
Elevated IgE levels herald T lymphocyte and macrophage infiltration. Pancreatic islet inflammation was linked to Gimap4, Gimap5, and other potential candidate genes on rat chromosome 4.
Authors
- Marika Bogdani (ORCID: https://orcid.org/0000-0002-4677-7523)
- Åke Lernmark (ORCID: https://orcid.org/0000-0003-1735-0499)
- Josefine Jönsson (ORCID: https://orcid.org/0000-0003-0709-2828)
- Stephanie Jerman
- Krysten E. Vance (ORCID: https://orcid.org/0000-0001-5647-1504)
- Jeanette Tångrot
- Linda Faxius
- Anita Ramelius (ORCID: https://orcid.org/0000-0003-2407-7785)
- Rasmus Bennet
- Doug Bowman
- Peter Ericsson
Institutions
- University of Washington (US)
- Indra (Spain) (ES)
- Skåne University Hospital (SE)
- Umeå University (SE)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1007/s00011-025-02101-9
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Barndiabetesfonden
- Diabetesfonden
- Sydvästra Skånes Diabetesförening