Age-Stratified Immune-Inflammatory Profiles and Prognostic Implications of Old Patients in the ICU: A Prospective Study
OPs, especially VOPs, with hemodynamically confirmed shock and critical illness exhibit distinct immune-inflammatory characteristics affecting prognosis. A weakened immune response in low inflammation links to poor outcomes. Enhancing B cell and CD8+DR+ T cell responses may improve prognosis through precise immune regulation in ICU settings.
Authors
- Guangjian Wang (ORCID: https://orcid.org/0000-0001-5117-7218)
- Xiaoting Wang (ORCID: https://orcid.org/0000-0002-7626-7305)
- Hua Zhao (ORCID: https://orcid.org/0000-0002-5507-9647)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-6996-353X)
- Hui Lian (ORCID: https://orcid.org/0000-0002-6542-9356)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s548582
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College
- National Science and Technology Major Project