Evaluating the effectiveness of intravenous alteplase in patients with minor non-disabling stroke and severe large vessel stenosis: a retrospective study
In summary, for patients with minor non-disabling stroke and severe large vessel stenosis or occlusion, intravenous alteplase administered within 4.5 h is associated with significantly better functional outcomes compared to DAPT, without increasing the risk of hemorrhagic complications. These findings support the use of thrombolysis in this specific patient population and highlight the need for randomized controlled trials to confirm these results.
Authors
- Xichang Liu
- Ying Tang (ORCID: https://orcid.org/0000-0002-3355-1541)
- Helen X. Hou (ORCID: https://orcid.org/0009-0007-3326-4319)
- Xijun Li (ORCID: https://orcid.org/0000-0002-2158-0783)
- Hailong Xu (ORCID: https://orcid.org/0000-0003-1223-1693)
- Zhifeng Huang (ORCID: https://orcid.org/0000-0001-8269-6731)
- Xuemei Li (ORCID: https://orcid.org/0000-0003-4120-0589)
- Zhenxing Liu (ORCID: https://orcid.org/0000-0003-1173-0044)
- Yan Yang (ORCID: https://orcid.org/0000-0002-3458-8047)
- Qiong Du (ORCID: https://orcid.org/0000-0003-4830-9704)
- Xiaoxuan Li (ORCID: https://orcid.org/0000-0002-5582-0300)
Institutions
- China Three Gorges University (CN)
- Gezhouba Central Hospital of Sinopharm (CN)
- Second Hospital of Yichang (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fneur.2025.1661549
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00