Comprehensive Analysis and Experimental Validation of Immune-Related Biomarkers and Immune Microenvironment in Diabetic Nephropathy
Our findings nominate <i>CCL9, EDN1</i>, and <i>HSPA1L</i> as key mediators of DN progression and unveil their potential as diagnostic biomarkers. Although prospective validation in human cohorts is a prerequisite for clinical translation, these IRGs represent a compelling foundation for a precision medicine tool. This tool could transform patient management by facilitating pre-symptomatic diagnosis and informing tailored interventions to halt DN development.
Authors
- Weixun Zhou (ORCID: https://orcid.org/0000-0002-7459-7343)
- Xunjia Li (ORCID: https://orcid.org/0000-0002-1182-2638)
- Ziyang Zeng (ORCID: https://orcid.org/0000-0003-0725-142X)
- Mei Yang (ORCID: https://orcid.org/0000-0002-0225-4237)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s541886
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00