DPP-4 inhibitor alleviates gut-brain axis pathology in Parkinson’s disease
These findings demonstrated that sitagliptin alleviated α-synuclein deposition in the gut and brain through modulation of TLR2-mediated inflammation and altered the gut microbiome composition towards a more favourable profile, which indicates that DPP-4is can offer a novel therapeutic avenue for managing PD.
Authors
- Seong Ho Jeong (ORCID: https://orcid.org/0000-0003-4439-4390)
- Jung Wook Lee (ORCID: https://orcid.org/0000-0002-8461-4741)
- Phil Hyu Lee (ORCID: https://orcid.org/0000-0001-9931-8462)
- Yeon Ju Kim (ORCID: https://orcid.org/0000-0002-5041-6704)
- Kyu Won Oh
- Jin Young Shin
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- New Generation University College (ET)
- Yonsei University Health System (KR)
- Catholic Kwandong University (KR)
Publication Details
- Journal
- Gut
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1136/gutjnl-2025-334988
- Citations
- 4
- Primary Topic
- Dysphagia Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 12.47