Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development
AnxA1 is implicated in microbiota control under healthy and IBD conditions. Accordingly, the microbiota of healthy AnxA1<sup>-/-</sup> mice, colitic AnxA1<sup>-/-</sup> mice, and IBD patients with low AnxA1 expression exhibit dysbiosis compared to their respective controls. Together, these unprecedented findings reveal AnxA1 as a potential regulatory protein in the immune-microbiota axis involved in IBD pathogenesis.
Authors
- Hermie J. M. Harmsen (ORCID: https://orcid.org/0000-0003-2725-6148)
- Klaas Nico Faber (ORCID: https://orcid.org/0000-0001-8893-3312)
- Gustavo Henrique Oliveira da Rocha
- Ranko Gaćeša (ORCID: https://orcid.org/0000-0003-2119-0539)
- Christian J. Hoffmann (ORCID: https://orcid.org/0000-0003-0861-2418)
- Fabiana da Silva Lima (ORCID: https://orcid.org/0000-0003-3695-4458)
- Milena Fronza Broering (ORCID: https://orcid.org/0000-0001-6748-882X)
- Luana Filippi Xavier (ORCID: https://orcid.org/0000-0002-1752-181X)
- Sandra Helena Poliselli Farsky (ORCID: https://orcid.org/0000-0002-3943-977X)
- Pablo Scharf (ORCID: https://orcid.org/0000-0003-4614-669X)
Institutions
- University Medical Center Groningen (NL)
- Universidade de São Paulo (BR)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1679071
- Citations
- 2
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 1.61