Decoding monocyte heterogeneity in sepsis: a single-cell apoptotic signature for immune stratification and guiding precision therapy
This study elucidates a critical facet of immune heterogeneity in sepsis through the identification of a validated, four-gene apoptotic signature in classical monocytes. Beyond its diagnostic utility, this signature serves as a molecular indicator of immune state, enabling refined patient stratification. These findings lay the groundwork for precision immunopharmacology, where apoptosis-targeted or anti-inflammatory therapies can be tailored to individual immune profiles.
Authors
- Wenjuan Duan (ORCID: https://orcid.org/0000-0001-7410-939X)
- Xiaorong Deng (ORCID: https://orcid.org/0000-0003-2239-3450)
- Haiying Zhou (ORCID: https://orcid.org/0009-0003-0731-4045)
- Wei Li (ORCID: https://orcid.org/0000-0002-3332-1287)
- Qi Chen (ORCID: https://orcid.org/0000-0001-6353-9589)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0472-3399)
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fphar.2025.1675887
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Chengdu Medical College