The role of ATG16L1 in Crohn’s disease and the structural alteration mechanisms and functional consequences of the rs2241880 variant
This finding not only provides the first molecular mechanism of the ATG16L1 T300A mutation, offering an important theoretical basis for understanding CD susceptibility differences, but also provides insights for precision medicine interventions and gene editing strategies.
Authors
- Shijie Ren (ORCID: https://orcid.org/0000-0003-3568-7124)
- Binbin Hu (ORCID: https://orcid.org/0000-0002-0443-1401)
- Jianping Liu (ORCID: https://orcid.org/0000-0001-7090-2112)
- Xin Kang (ORCID: https://orcid.org/0000-0001-6723-2007)
- Jingyuan Liu (ORCID: https://orcid.org/0000-0001-5624-1258)
- Xingchi Liu (ORCID: https://orcid.org/0000-0003-1298-8098)
- Wenli Wei
- Wen-Jing Zhai
- X Lang
- Yifan Zhang (ORCID: https://orcid.org/0009-0001-0873-3853)
- Qiang Chuai
Institutions
- Hebei University of Chinese Medicine (CN)
- Affiliated Hospital of Hebei University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fmed.2025.1656575
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00