Unveiling the mechanisms of American ginseng and achyranthes in treatment of primary Sjogren’s syndrome via mtDNA-cGAS-STING pathway insights from network pharmacology, molecular dynamics, and experimental validation

The critical components baicalin and quercetin from AG&A, particularly in aqueous extracts, exhibit therapeutic efficacy against pSS. This study provides experimental evidence for their action mechanism through modulating the mtDNA-cGAS-STING pathway. While highlighting their therapeutic potential, additional <i>in vivo</i> and clinical studies are warranted to validate these findings.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-10-03
DOI
https://doi.org/10.3389/fimmu.2025.1675429
Citations
3
Primary Topic
Ginseng Biological Effects and Applications
Type
article
Field-Weighted Citation Impact
2.42
Controls
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article

Unveiling the mechanisms of American ginseng and achyranthes in treatment of primary Sjogren’s syndrome via mtDNA-cGAS-STING pathway insights from network pharmacology, molecular dynamics, and experimental validation

Jin Chen, Yanzhi Song, Congmin Xia, Haotian Li et al.
3 citations
Frontiers in Immunology
Ginseng Biological Effects and Applications
2.42
article

Unveiling the mechanisms of American ginseng and achyranthes in treatment of primary Sjogren’s syndrome via mtDNA-cGAS-STING pathway insights from network pharmacology, molecular dynamics, and experimental validation

Jin Chen, Yanzhi Song, Congmin Xia, Haotian Li, Yanjun Liu
article en
3 citations

Abstract

The critical components baicalin and quercetin from AG&A, particularly in aqueous extracts, exhibit therapeutic efficacy against pSS. This study provides experimental evidence for their action mechanism through modulating the mtDNA-cGAS-STING pathway. While highlighting their therapeutic potential, additional <i>in vivo</i> and clinical studies are warranted to validate these findings.

Frontiers in ImmunologyVol. 16
Beijing University of Chinese Medicine (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), China Academy of Chinese Medical Sciences (CN), Guang’anmen Hospital (CN)
Openalex Percentile: Top 10%
Ginseng Biological Effects and Applications
2.42
DOIOpen Access PDFOpenAlex
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Unveiling the mechanisms of American ginseng and achyranthes in treatment of primary Sjogren’s syndrome via mtDNA-cGAS-STING pathway insights from network pharmacology, molecular dynamics, and experimental validation — Jin Chen, Yanzhi Song, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS