SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

These findings demonstrate that SIRT3 protects against hypoxia-induced endothelial cell injury by inhibiting autophagy-dependent ferroptosis through activation of the PI3K/Akt/mTOR signaling pathway. The in vivo results further support a protective role of SIRT3 in alleviating PIH. This study reveals a novel SIRT3-mediated regulatory mechanism in PIH pathophysiology, suggesting that targeting SIRT3 and its downstream signaling may represent a potential therapeutic strategy for the management of PIH.